Studies on receptor signaling and regulation in platelets.

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Dissertation Pathophysiology of cutaneous T-cell lymphoma.

Dissertation Pathophysiology of cutaneous T-cell lymphoma: Understanding of neoplastic T-cells and non-malignant infiltrate in lesional skin submitted by Pablo Augusto VIEYRA GARCIA for the Academic Degree of Doctor of Philosophy (PhD) at the Medical University of Graz Department of Dermatology under the Supervision of Prof. Dr. Peter WOLF 2016. 2 Hereby, I disclose that part of the results.

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Refubium - Induktion regulatorischer T Zellen bei.

DISSERTATION Submitted to the Combined Faculties for the Natural Sciences and for Mathematics of the Ruperto-Carola University of Heidelberg, Germany for the degree of Doctor of Natural Sciences Presented by: Dipl.-Biol. Eva Schlecker Born in Illertissen Oral examination: 14.07.2011. The role of tumor-infiltrating MDSC subsets in tumor progression Referees: Prof. Dr. Viktor Umansky PD Dr.

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Targeted transduction of T cell subsets for immunotherapy.

Immunological and translational consequences of an altered CD8 T cell cytolytic activity. Einloggen; Hilfe; Kontakt; Impressum; Datenschutz; Deutsch.

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Die Rolle regulatorischer T-Zellen im. - CORE.

Dissertation The Effect of Glucagon Like Peptide-1 Receptor Agonism in T Cell Mediated Diseases: A Thorough Study of the Case of Nephrotoxic Serum Nephritis submitted by MSc Foteini MOSCHOVAKI FILIPPIDOU for the Academic Degree of Doctor of Philosophy (PhD) at the Medical University of Graz Clinical Division of Nephrology Department of Internal Medicine under the supervision of Assoz. Prof.

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Dissertation The role of regulatory immune cells in autoimmunity and immune tolerance in type 1 diabetes submitted by Mag.rer.nat. Barbara PRIETL For the Academic Degree of Doctor of Philosophy (PhD) at the Medical University of Graz Department of Internal Medicine Division of Endocrinology and Diabetology under the Supervision of Prof. Dr. Thomas PIEBER 2016. 2 Statutory Declaration “I.
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Refubium - Immunological and translational consequences of.

Dissertation's 47 research works with 19 citations and 409 reads, including: Asset Pricing and Portfolio Choice in the Presence of Housing.

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ULB Bonn ::: Dissertation - Tomabu G. Adjobimey.

COVID-19 Resources. Reliable information about the coronavirus (COVID-19) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this WorldCat.org search.OCLC’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle coronavirus.

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Dissertation The role of regulatory immune cells in.

In the first part of this thesis, high expression of FAT10 in the thymus could be assigned to medullary thymic epithelial cells. These cells play an essential role in negative selection and central tolerance induction as they present self-antigens to developing thymocytes and promote elimination of self-reactive T cells. FAT10 expression was primarily detected in terminally differentiated.

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Immune Cells in Renal Disease: Regulatory T Cells in.

The objective of this Ph.D. thesis was to investigate the role of regulatory T cells (Tregs) in physiological and pathological bone remodeling. We first in vitro characterized the suppressive effects of Tregs on the differentiation of the bone resorptive cells or osteoclasts. The effect was found to be directly mediated and to require cell to cell contact between the monocytic precursors of.

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In this thesis, CD8 T cells showed subset specific differences in their metabolic activity. While glucose restriction did not harmed T cell function, glutamine deprivation had a strong impact on the T cell immune response. Therefore, targeting glucose metabolism is a promising strategy in cancer therapy, while drugs acting on the glutamine metabolism have to be considered carefully.
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Delivery of Cytomegalovirus T cell antigens for diagnostic.

This thesis identified a novel role of the immunoproteasome subunit LMP7 in the progression of autoimmune diseases like rheumatoid arthritis and colitis. We also looked into the molecular details of this novel finding focussing on transcription factors and regulatory proteins especially with respect to different T-helper cell differentiation pathways like Th1, Th17, and Tregs, which are.

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Regulation of CD4 T cell functions by the p38 mitogen.

A thesis submitted to attain the degree of DOCTOR OF SCIENCES OF ETH ZURICH (DR. SC. ETH ZURICH) presented by JOSHUA MARK CROUSE MSc ETH, ETH Zurich born on 8.12.1985 citizen of USA accepted on the recommendation of Prof. Dr. Annette Oxenius (examiner) Prof. Dr. Antonio Lanzavecchia (co-examiner) Prof. Dr. Dietmar Zehn (co-examiner) 2014. II. III “Never allow the fear of striking out keep.

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The Ubiquitin-like modifier FAT10 in tolerance induction.

Dissertation: Abstract: Prognostic significance of CD28 autoantibodies in patients with malignant melanoma under therapy with ipilimumab For an effective response, the two opponents CD28 and CTLA-4 on T cells are crucial. While the CD28 receptor as a costimulatory receptor has the role as a catalyst during the immune response, CTLA-4 has blocking effects and downregulates the immune response.

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Die Rolle regulatorischer T-Zellen im experimentellen.

Hemophilia A is a bleeding disorder, affecting about 400 000 people worldwide. In addition to prolonged bleeding times, patients suffer from spontaneous and internal bleedings, affecting their everyday life. Patients can be treated by the application of therapeutic FVIII, either derived from plasma or recombinantly produced. Whether the treatment is prophylactic or on-demand depends on the.

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Summer savory ( Satureja hortensis L., Lamiaceae ) is used in several regions of the world as a spice and folk medicine. Anti-inflammatory and cytoprotective effects of S. hortensis and of its rosmarinic acid-rich phenolic fraction have been demonstrated in animal trials. However, previous studies of rosmarinic acid in cell models have yielded controversial results.

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Activated protein C protects from GvHD by inducing.

Aim of the thesis 19 3. Results (manuscripts) 21 3.1 Impaired T cell development in the absence of Vav1 and Itk 23 Raberger et al., Eur J Immunol. 2008 Nov 3.2 The transcriptional regulator PLZF induces the development of CD44-high memory-phenotype T cells 37 Raberger et al., PNAS 2008 Nov 3.3 The protein tyrosine kinase Tec regulates IL-17-producing memory-like T cells 53 Boucheron et al.

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